Table 1. Ldb1-complex and Klf1 co-activated genes.
Gene Ontology Term | Ldb1-complex/Klf1 Co-activated Genes |
---|---|
Membrane/ Cytoskeleton/ Blood group |
Cd24a, Cd47, Cd59a, Ermap, Gypa, Gypc, Kcnn4, Kel, Mgll, Rhd, Slc4a1, Slc2a4, Slc22a4, Tmcc2, Vamp5, Fam210b, Sppl2b |
Cytoskeleton | Add2, Ank1, Epb4.1, Epb4.2, Spna1, Spnb1 |
Heme Synthesis & Transport/ Mitochondrial |
Abcb10, Abcg2, Alad, Alas2, Blvrb, Bzrap1, Cat, Cpox, Fech, Hagh, Hmbs, Ppox, Urod, Vdac1 |
Hb/Iron Procurement |
Fxn, Hba, Hbb, Ppox, Slc25a37/mitoferrin, Slc11a2/Dmt1, Steap3, Tfrc |
Apoptosis/ Survival/Cell cycle |
Cdkn2c/p 18INK4c, Ctsb, Dlgap5, Pim1, Prdx2, Ptp4a3, Rad23a, Rgcc |
Cytoplasmic | Arrb1, Dck, Pcx, Stx2, Ube2c, Ubap1 |
Nuclear/ Transcription |
Cdyl, E2f2, Mafk |
Genes included in the table are those significantly down-regulated in Ldb1 shRNA-mediated knock down Murine Erythroleukemia cells and in Klf1−/−fetal liver cells. Color code: Black, genes bound by Ldb1-complex(es) (gene body ± 10 Kb) and by Klf1; Blue, genes bound only by Klf1; Red, genes bound only by Ldb1-complex(es) (gene body ± 10 Kb); Green, genes not bound by Ldb1-complexes or Klf1. Gene list was compiled from published articles [8, 25, 40, 58].