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Hydroxyurea (HU) cellular accumulation and protein binding in vitro. A: intracellular accumulation of hydroxyurea in ooctyes that overexpress rodent organic anion transporting polypeptide 1B (Oatp1b2) transporters or water-injected controls after 30 min of incubation in the presence or absence of Oatp1b2 inhibitors (n = 8–12; *P = 0.0001 compared with all other conditions). B: fraction of unbound hydroxyurea in mouse or human plasma as determined by equilibrium dialysis (n = 3).
