Fig. 4.
Amiloride dose-response curves. Whole cell Na+ currents were measured in oocytes expressing wild-type (○) or αβγ-βTM2 (●) channels in the presence of increasing concentrations of amiloride. Currents were normalized to the basal current in the absence of amiloride to obtain normalized whole cell currents (I/I0) values. Each data point represents the mean value from 7 to 18 measurements ± SE. Data were fit to the equation described in experimental procedures. Error bars are within symbols.