Fig. 1.

Metabolic parameters of pubertal and postpubertal female mice lacking agouti gene-related peptide (AGRP) and/or leptin receptor (LEPR)-B. A: weight gain and body composition of wild-type controls and Lepr^db/db, Lepr^db/db Agrp^−/−, and Agrp^−/− mice (n = 6–9). B: fasting glucose levels of wild-type controls and Lepr^db/db, Lepr^db/db Agrp^−/−, and Agrp^−/− mice at 4, 5, and 8 wk of age (n = 5–8). C: fasting insulin levels of wild-type controls and Lepr^db/db, Lepr^db/db Agrp^−/−, and Agrp^−/− mice. Data are presented as means ± SE. *P < 0.05 compared with wild-type; #P < 0.05 compared with genotype-matched preceding age group.