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Loss of Agrp affects the timing of vaginal opening. A: mean age at the time of vaginal opening in wild-type controls and Leprdb/db, Leprdb/db Agrp−/−, and Agrp−/− mice. B: cumulative percentage of wild-type controls and Leprdb/db, Leprdb/db Agrp−/−, and Agrp−/− mice with vaginal opening is presented relative to age. Data are presented as means ± SE (n = 11–63). *P < 0.05 compared with all other groups, respectively.
