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. 2013 Oct 29;305(12):E1512–E1520. doi: 10.1152/ajpendo.00241.2013

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Fig. 8. — A network of leptin-sensitive neurons modulates gonadotropin-releasing hormone (GnRH) neurons. AGRP/neuropeptide Y (NPY) neurons of the ARC send inhibitory signals (red arrows) to proopiomelanocortin, KNDy neurons, and GnRH neurons. Presence of LEPR and melanocortin receptor 4 (MC4R) expression is represented on the neurons. MPOA, medial preoptic area; CART, cocaine amphetamine-related transcript; NOS, nitric oxide synthase; PMV, ventral premamillary nucleus; KISS, kisspeptin; NKB, neurokinin B; DYN, dynorphin.