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. 2013 Oct 29;305(12):E1512–E1520. doi: 10.1152/ajpendo.00241.2013

Table 1.

Agrp KO restores pregnancy and lactation in Leprdb/db mice

Genotype Days From Mating to Birth of Litter Pups Born Pups Weaned
Leprdb/dbAgrp−/− 22 ± 2* (11 litters) 5.3 (4–8 pups)* 5.3 (4–8 pups)*
Leprdb/db 38 (1 litter) 1 pup 0

Lepr, leptin receptor; KO, knockout. Breeding tests revealed that Agrp−/− Leprdb/db females have successful pregnancy, parturition, and lactation (n = 12).

*

P < 0.05 compared with Leprdb/db.