Table 5.
Clinical and pathological characteristics of the 113 patients with pathological N0 stage, according to treatment n (%)
| pN0 Surgery alone 40 (35.4) | ypN0 Neoadjuvant chemotherapy and surgery 73 (64.6) | P value | ||
| Preoperative status | ||||
| Age (range) yr1 | 73.62 (56.73-85.41) | 65.59 (32.77-78.43) | < 0.0001 | |
| Sex ratio (M:F)1 | 31 (77.5):9 (22.5) | 66 (90.4):7 (9.8) | 0.061 | |
| cT stage | 1 | 13 (32.5) | 0 (0) | < 0.0001 |
| 2 | 17 (42.5) | 9 (12.3) | ||
| 3 | 10 (25) | 61 (83.6) | ||
| 4 | 0 (0) | 3 (4.1) | ||
| cN stage | 0 | 27 (67.5) | 13 (17.8) | < 0.0001 |
| 1 | 13 (32.5) | 60 (82.2) | ||
| cM stage | 0 | 40 (100) | 71 (97.3) | 0.293 |
| 1 | 0 (0) | 2 (2.8) | ||
| Performance status | 0 | 3 (9.4) | 16 (21.9) | 0.045 |
| 1 | 25 (78.1) | 54 (74) | ||
| 2 | 4 (12.5) | 3 (4.1) | ||
| ASA | 1 | 2 (5) | 6 (8.2) | 0.268 |
| 2 | 31 (77.5) | 59 (80.8) | ||
| 3 | 7 (17.5) | 8 (11) | ||
| O-POSSUM1 | 17 (14-29) | 16 (12-26) | 0.015 | |
| Tumour site | Middle 1/3 | 0 (0) | 1 (1.4) | 0.190 |
| Lower 1/3 | 15 (37.5) | 35 (47.9) | ||
| OGJ-S1 | 11 (27.5) | 12 (16.4) | ||
| OGJ-S2 | 8 (20) | 16 (21.9) | ||
| OGJ-S3 | 6 (15) | 9 (12.3) | ||
| Operative outcomes | ||||
| Length of operation (min)1 | 240 (120-360) | 278 (120-471) | 0.082 | |
| Blood loss (mL)1 | 200 (0-2200) | 350 (0-3000) | 0.167 | |
| Clavien Dindo Max | 0 | 14 (35) | 24 (32.9) | 0.709 |
| 1 | 1 (2.5) | 3 (4.1) | ||
| 2 | 17 (42.5) | 27 (37) | ||
| 3 | 4 (10) | 10 (13.7) | ||
| 4 | 2 (5) | 9 (12.3) | ||
| 5 | 2 (5) | 0 (0) | ||
| Anastomotic leaks | 4 (10) | 7 (9.6) | 0.944 | |
| Pathological outcomes | ||||
| TRG 1-2 | - | 34 (46.6) | NA | |
| TRG 3-5 | - | 39 (53.4) | ||
| pT or ypT | 0 | 2 (5) | 11 (15.1) | 0.224 |
| 1 | 22 (55) | 20 (27.4) | ||
| 2 | 5 (12.5) | 20 (27.4) | ||
| 3 | 10 (25) | 24 (32.9) | ||
| 4 | 0 (0) | 1 (1.4) | ||
| Nodal Downstaged (cN1 to p or ypN0) | 15 (37.5) | 61 (83.6) | < 0.0001 | |
| Nodal yield1 | 16 (4-49) | 18 (3-52) | 0.150 | |
| Resection clearance | R0 | 35 (87.5) | 69 (94.5) | 0.189 |
| Vascular invasion | 7 (17.5) | 10 (13.7) | 0.590 | |
| Lymphatic invasion | 2 (5) | 6 (8.2) | 0.525 | |
| Perineural invasion | 2 (5) | 5 (6.8) | 0.698 | |
| Maximum tumour diameter (mm)1 | 24 (0-50) | 24 (0-110) | 0.324 | |
| Morphology | Ulcer | 25 (65.8) | 53 (79.1) | 0.135 |
| Polypoid | 10 (26.3) | 11 (16.4) | ||
| Fungating | 1 (2.6) | 1 (1.5) | ||
| Diffuse infiltrating | 2 (5.3) | 2 (3) | ||
| Grade | G1 | 4 (10) | 13 (17.8) | 0.811 |
| G2 | 17 (42.5) | 20 (27.4) | ||
| G3 | 19 (47.5) | 40 (54.8) | ||
| G4 | 0 (0) | 0 (0) | ||
| Site of recurrence | Local | 0 (0) | 2 (2.7) | 0.293 |
| Nodal | 1 (2.5) | 4 (5.5) | 0.463 | |
| Distant | 3 (7.5) | 12 (16.4) | 0.182 |
Values in parentheses are percentages unless indicated.
1
Values in parentheses are range. ASA: American society of anesthesiologists classification; O-POSSUM: Oesophagogastric surgery-physiological and operative severity score for the enumeration of mortality and morbidity; NA: Not available.