Table 2.
Changes in biochemical data after surgery according to the follow up period and operation type
| Operation type | Preoperative | PO 3 mo | PO 6 mo | PO 12 mo | 1P pre-12 mo | |
| BMI (kg/m2) | STG BI | 24.3 ± 2.9 | 22.5 ± 2.6 | 22.3 ± 2.8 | 21.9 ± 2.7 | < 0.001 |
| STG BII | 24.7 ± 3.1 | 22.6 ± 2.9 | 22.9 ± 2.1 | 22.1 ± 1.9 | 0.002 | |
| TG | 25.7 ± 5.2 | 23.8 ± 5.7 | 22.5 ± 4.6 | 22.9 ± 4.4 | 0.004 | |
| 2P | 0.793 | 0.965 | 0.616 | 0.780 | ||
| BMI | STG BI | 100% | 92.9% ± 5.2% | 92.2% ± 5.3% | 92.0% ± 7.0% | < 0.001 |
| STG BII | 100% | 91.6% ± 6.7% | 93.3% ± 6.9% | 90.3% ± 11.0% | 0.004 | |
| TG | 100% | 90.9% ± 6.4% | 87.8% ± 5.7% | 87.1% ± 8.1% | 0.003 | |
| 2P | 1.000 | 0.661 | 0.050 | 0.333 | ||
| Glucose (mg/dL) | STG BI | 147.3 ± 44.1 | 125.0 ± 30.3 | 122.3 ± 38.4 | 114.4 ± 21.7 | 0.001 |
| STG BII | 155.7 ± 40.0 | 136.4 ± 56.6 | 122.5 ± 31.9 | 126.4 ± 39.1 | 0.061 | |
| TG | 145.9 ± 37.5 | 114.3 ± 22.2 | 117.0 ± 28.0 | 115.4 ± 27.3 | 0.234 | |
| 2P | 0.682 | 0.489 | 0.931 | 0.773 | ||
| HbA1c | STG BI | 7.2% ± 1.1% | 6.8% ± 0.6% | 7.0% ± 0.7% | 7.1% ± 0.9% | 0.834 |
| STG BII | 7.3% ± 1.3% | 6.9% ± 1.4% | 7.1% ± 1.3% | 7.1% ± 1.6% | 0.626 | |
| TG | 7.1% ± 0.8% | 6.5% ± 0.7% | 6.5% ± 0.5% | 6.5% ± 0.6% | 0.119 | |
| 2P | 0.981 | 0.227 | 0.201 | 0.201 | ||
| Insulin (μIU/mL) | STG BI | 21.3 ± 20.7 | 8.6 ± 11.2 | 8.1 ± 11.3 | 5.1 ± 4.7 | < 0.001 |
| STG BII | 22.5 ± 29.0 | 9.6 ± 8.8 | 8.9 ± 3.5 | 7.7 ± 7.1 | 0.041 | |
| TG | 18.1 ± 10.1 | 7.5 ± 5.7 | 4.0 ± 2.1 | 3.7 ± 1.9 | 0.02 | |
| 2P | 0.679 | 0.652 | 0.050 | 0.350 | ||
| C-peptide (ng/mL) | STG BI | 3.4 ± 2.3 | 2.1 ± 1.6 | 2.3 ± 1.2 | 1.5 ± 0.8 | < 0.001 |
| STG BII | 3.3 ± 1.8 | 2.0 ± 1.4 | 2.4 ± 0.9 | 2.1 ± 1.5 | 0.028 | |
| TG | 2.8 ± 1.3 | 2.1 ± 1.2 | 1.5 ± 1.3 | 1.6 ± 0.6 | 0.02 | |
| 2P | 0.877 | 0.778 | 0.597 | 0.523 | ||
| HOMA-IR | STG BI | 8.7 ± 10.1 | 2.9 ± 4.7 | 2.6 ± 7.9 | 1.3 ± 0.9 | 0.001 |
| STG BII | 9.3 ± 13.5 | 3.3 ± 3.4 | 2.9 ± 2.0 | 2.5 ± 2.5 | 0.045 | |
| TG | 7.1 ± 4.1 | 2.1 ± 1.6 | 0.8 ± 0.2 | 1.1 ± 0.6 | 0.015 | |
| 2P | 0.660 | 0.484 | 0.036 | 0.176 | ||
| TG (mg/dL) | STG BI | 126.1 ± 80.8 | 100.1 ± 51.6 | 115.9 ± 62.6 | 101.4 ± 41.7 | 0.341 |
| STG BII | 144.8 ± 102.6 | 118.5 ± 75.9 | 124.3 ± 53.7 | 105.2 ± 44.6 | 0.114 | |
| TG | 143.5 ± 88.9 | 130.5 ± 71.4 | 72.3 ± 36.6 | 96.6 ± 37.3 | 0.082 | |
| 2P | 0.831 | 0.503 | 0.130 | 0.937 | ||
| LDL (mg/dL) | STG BI | 96.8 ± 34.7 | 89.0 ± 27.9 | 81.3 ± 23.5 | 90.8 ± 29.2 | 0.522 |
| STG BII | 97.4 ± 28.7 | 97.9 ± 33.5 | 94.4 ± 29.7 | 101.6 ± 37.5 | 0.515 | |
| TG | 113.6 ± 28.9 | 99.8 ± 28.0 | 63.5 ± 32.0 | 98.5 ± 32.0 | 0.023 | |
| 2P | 0.299 | 0.556 | 0.192 | 0.594 | ||
| HDL (mg/dL) | STG BI | 43.9 ± 10.6 | 48.3 ± 11.4 | 49.4 ± 15.1 | 52.0 ± 15.1 | 0.002 |
| STG BII | 43.2 ± 9.2 | 42.6 ± 8.2 | 46.2 ± 10.6 | 46.5 ± 8.6 | 0.173 | |
| TG | 42.4 ± 10.5 | 45.0 ± 7.3 | 48.7 ± 3.2 | 46.3 ± 8.1 | 0.073 | |
| 2P | 0.953 | 0.161 | 0.757 | 0.552 |
1Paired t-test, mean ± SD;
2
Kruskal-Wallis test was used to evaluate the difference by operation type at the same follow up period. Significant values are indicated in bold face. BMI: Body mass index, BMI (%) refers to percentage of BMI at each follow-up compared to preoperative BMI. STG BI: Subtotal gastrectomy with Billroth I anastomosis; STG BII: Subtotal gastrectomy with Billroth II anastomosis; TG: Total gastrectomy; HOMA-IR: Homeostasis model assessment-estimated insulin resistance; LDL: Low-density lipoprotein; HDL: High-density lipoprotein.