Table 3.
Survival variable |
Disease-free survival |
Overall survival |
||||
95%CI2 | P value | HR1 | 95%CI2 | P value | HR1 | |
Univariate analysis | ||||||
KLK10 | ||||||
Negative | 1.00 | 1.00 | ||||
Positive | 0.25-0.74 | 0.002 | 0.46 | 0.26-0.79 | 0.005 | 0.43 |
Age | 0.97-1.01 | 0.46 | 0.99 | 0.97-1.01 | 0.49 | 0.99 |
Sex | 0.55-1.53 | 0.75 | 0.90 | 0.54-1.51 | 0.69 | 0.92 |
Depth of invasion | 1.55-2.81 | < 0.001 | 2.13 | 1.57-2.89 | < 0.001 | 2.08 |
Lymph node metastasis | 0.97-1.97 | 0.07 | 1.42 | 0.99-2.02 | 0.051 | 1.38 |
Histology | 6.42-22.46 | < 0.001 | 10.25 | 5.73-18.32 | < 0.001 | 12.01 |
Multivariate analysis | ||||||
KLK10 | ||||||
Negative | 1.00 | 1.00 | ||||
Positive | 0.31-0.96 | 0.03 | 0.58 | 0.33-1.02 | 0.06 | 0.55 |
Age | 0.95-1.00 | 0.02 | 0.97 | 0.95-0.99 | 0.04 | 0.97 |
Sex | 0.77-2.22 | 0.31 | 1.33 | 0.77-2.28 | 0.30 | 1.31 |
Depth of invasion | 0.99-1.90 | 0.06 | 1.42 | 1.02-1.98 | 0.03 | 1.37 |
Lymph node metastasis | 0.84-1.59 | 0.35 | 1.21 | 0.87-1.67 | 0.24 | 1.16 |
Histology | 6.55-25.41 | 0.03 | 11.11 | 5.87-21.02 | < 0.001 | 12.90 |
Hazard ratio (HR) estimated from Cox proportional hazard regression model;
Confidence interval of the estimated HR. KLK10: Kallikrein gene 10.