Figure 1.
Alternative isoforms of ATP2A1 and RYR1 in muscle biopsies from DM1, DM2 and non-DM dystrophy (NMD) patients compared to muscle of normal individuals. Panels a and c show design for RT-PCR assays. Panels b and d show results of quantitative fluorescent RT-PCR. Percent inclusion of the aberrantly spliced exon is shown on the Y axis. Error bars represent the standard deviation for each group. DM1 was not significantly different from normal for RYR1 (p-value = 0.251), while DM2 was (p-value = 0.0239). For ATP2A1 both DM1 and DM2 were significantly different from normal (p-value = 0.0211 and p-value = 2.68E-11, respectively)