Table 2.

Summary of gene and protein expression in DM1 and DM2

Gene	Protein	IHCa,b		EP	SVA	WB
		DM1	DM2
RYR1	RYR1	-	-	no change	exon 70 exclusionc	no change
CACNA1S	DHPR	-	=	no change	na	no change
ATP2A1	SERCA1	=	=	↑	exon 22 exclusion	no change
ATP2A2	SERCA2	na	=	↑	na	N > DM2
CASQ1	CASQ1	na	=	↑	na	no change
CASQ2	CASQ2	-	--	↑	na	no change
TRDN	TRDN	na	=	↑	na	DM2 > DM1
JPH1	JPH1	-	=	↑	na	N > DM
PPP3CA	Calcineurin	na	=	↑	na	DM2 > DM1
NFATC3	NFATC3	na	na	no change	na	DM2 > DM1

IHC, immunohistochemistry; EP microarray expression profiling; SVA, splice variant analysis; WB, western blotting; na, not assessed.

^aFibres > 30–40 um in diameter, most of which presumably contractile.

^bEvaluation of protein expression: =, staining similar to healthy control; -, moderately reduced; --, severely reduced.

^cStatistically significant only in DM2