Fig. 4.

Effects of renal cell transplantation on glomerulosclerosis and vascular density. Significantly decreased glomerulosclerosis and improved microvascular density were observed in rats that received SAA-expressing cell transplants. Glomerulosclerosis was evaluated in trichrome-stained sections and vascular density by immunostaining with anti-von Willebrand factor antibody. Quantification is shown in the graphs. For numbers of glomeruli/group measured, n = 1,054 for the SA group, 888 for the SB group, 1,050 for the IA group, and 1,363 for the IB group. For numbers of ×200 microscope fields/group, n = 8 for the SA group, 15 for the SB group, 32 for the IA group, and 16 for the IB group. Scale bar = 50 μm. *P < 0.05 vs. SA; §P < 0.05 vs. IA.