Table 1.
Weight, g |
Glucose, mg/dl |
|||||||
---|---|---|---|---|---|---|---|---|
Group | 10 wk | 16 wk | 20 wk | 34 wk | 10 wk | 16 wk | 20 wk | 34 wk |
SA | 319 ± 9.2 | 426 ± 5.5 | 488 ± 7.9 | 566 ± 9.8 | 170 ± 18 | 173 ± 16 | 175 ± 15 | 158 ± 5.5 |
SB | 317 ± 9.2 | 426 ± 6.8 | 487 ± 6.1 | 577 ± 4.2 | 166 ± 8.1 | 161 ± 9.7 | 180 ± 5.9 | 154 ± 3.2 |
IA | 321 ± 9.5 | 426 ± 10 | 479 ± 11 | 552 ± 17 | 174 ± 8.8 | 175 ± 9.0 | 173 ± 14 | 150 ± 6.2 |
IB | 311 ± 9.9 | 427 ± 11 | 481 ± 11 | 584 ± 28 | 174 ± 9.4 | 169 ± 16 | 182 ± 10 | 155 ± 5.1 |
Lean | 314 ± 34 | 414 ± 10 | 478 ± 16 | 530 ± 12 | 122 ± 7.6 | 137 ± 5.2 | 124 ± 3.2 | 137 ± 1.3 |
Rats were divided into the following groups: rats subjected to sham operation and that received control, serum amyloid A (SAA)-negative tubular cells (SA group), rats subjected to sham operation and that received SAA-expressing tubular cells (SB group), rats subjected to renal ischemia and that received control, SAA-negative tubular cells (IA group), and rats subjected to renal ischemia and that received SAA-expressing tubular cells (IB group). Lean rats were lean, age-matched male Zucker/SHHF F1 hybrid rats. Mean blood glucose in the diabetic groups (SA, SB, IA, and IB groups) was significantly greater than in lean animals at each time point.