Figure 4.

Prediction of the time evolution of changes in fibril length during fragmentation. Left contour diagram depicts predicted time evolution of the fibril length distribution of a fibril sample undergoing fibril fragmentation. Shown in the right column are purple lines indicating the corresponding predicted length distributions as fragmentation precedes compared with experimental validation data consisting of normalized histograms of the length distribution of the fibril sample at the same time points, determined by TM-AFM imaging and image analysis. The fibril length distribution histograms shown are each constructed from 390 to 1200 individual fibril particles on 4–10 images. The scale corresponding to the fibril particle concentrations for each sample is shown to the right of the plots. To see this figure in color, go online.