Table 2.
Genotype-phenotype association analysis for variants genotyped in stage 2 analysis
|
Characteristic |
PSA
†
(n = 462) |
Family PCa
†
(n = 458) |
Family Ca
†
(n = 451) |
Age of PCa presentation
¥
(n = 265) |
Gleason score
¥
(n = 180) |
Grade
¥
(n = 147) |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Marker (risk allele) | OR (95% CI) ‡* | P § | Q ¶ | OR (95% CI) ‡ | P § | Q ¶ | OR (95% CI) ‡ | P§ | Q ¶ | OR (95% CI) ‡ | P § | Q ¶ | OR (95% CI) ‡ | P § | Q ¶ | OR (95% CI) ‡ | P § | Q ¶ |
| rs6983561 (C) |
1.35 (1.04-1.74) |
0.02 |
0.40 |
1.40 (0.86-2.27) |
0.18 |
0.60 |
0.91 (0.51-1.62) |
0.75 |
0.84 |
0.81 (0.57-1.15) |
0.24 |
0.68 |
1.11 (0.72-1.71) |
0.63 |
0.81 |
1.73 (1.03-2.92) |
0.04 |
0.35 |
| rs1859962 (G) |
1.28 (0.96-1.71) |
0.09 |
0.60 |
1.00 (0.61-1.65) |
0.99 |
0.99 |
0.58 (0.29-1.16) |
0.12 |
0.60 |
0.95 (0.64-1.42) |
0.82 |
0.86 |
1.22 (0.76-1.95) |
0.42 |
0.76 |
1.84 (1.05-3.22) |
0.03 |
0.35 |
| rs13254738 (C) |
1.15 (0.87-1.52) |
0.33 |
0.60 |
1.04 (0.61-1.79) |
0.88 |
0.93 |
1.12 (0.67-1.89) |
0.66 |
0.79 |
1.06 (0.73-1.54) |
0.75 |
0.86 |
0.72 (0.46-1.13) |
0.15 |
0.68 |
1.16 (0.67-1.99) |
0.60 |
0.81 |
| rs10090154 (T) |
0.89 (0.64-1.24) |
0.50 |
0.75 |
0.70 (0.34-1.43) |
0.33 |
0.60 |
1.44 (0.74-2.79) |
0.29 |
0.60 |
1.03 (0.64-1.65) |
0.91 |
0.91 |
0.79 (0.43-1.44) |
0.43 |
0.76 |
1.28 (0.66-2.47) |
0.47 |
0.76 |
| rs4242382 (A) |
0.81 (0.61-1.09) |
0.17 |
0.60 |
0.87 (0.50-1.50) |
0.62 |
0.79 |
1.20 (0.66-2.18) |
0.54 |
0.75 |
1.06 (0.72-1.57) |
0.78 |
0.86 |
1.21 (0.74-1.96) |
0.45 |
0.76 |
1.46 (0.83-2.56) |
0.19 |
0.68 |
| rs1465618 (A) | 1.29 (0.80-2.08) | 0.29 | 0.60 | 1.46 (0.68-3.16) | 0.33 | 0.60 | 1.43 (0.58-3.47) | 0.44 | 0.71 | 0.71 (0.39-1.29) | 0.26 | 0.68 | 1.54 (0.80-2.95) | 0.20 | 0.68 | 1.30 (0.56-3.01) | 0.54 | 0.81 |
† Genotype-phenotype association analysis for PSA (<20 μg/L = 0, ≥20 μg/L = 1), Family PCa (defined as first degree relatives affected by prostate cancer; no = 0, yes = 1) and Family Ca (defined as first and second degree relatives affected with any cancer; no = 0, yes = 1) was performed using all available samples (cases and controls).
¥ Genotype-phenotype association analysis for Age of prostate cancer presentation (<70 yrs = 1, ≥70 yrs = 0), Gleason score (≤7 = 0, >7 = 1) and tumor Grade (well/moderate = 0, poor = 1) was performed on prostate cancer cases only.
‡OR (odds ratios) and 95% CI (confidence intervals) were estimated using unconditional logistic regression models.
*PSA estimates were additionally controlled for Age.
§Un-corrected P-values derived using logistic regression analysis.
¶Benjamini and Hochberg’s method to correct for false discovery rate [26] was used to generate Q-values.