Fig. 5.

No phenotypic changes were detected in P30 TACE Ep-CKO or EM-CKO lung. A: cell proliferation was examined by PCNA immunostaining. No significant difference was observed for PCNA-positive cells among the lungs of TACE Ep-CKO, EM-CKO, and wild-type mice. B and C: immunostaining of molecular markers for differentiated lung cells, including type II alveolar epithelial cells (SP-C), club cells (CCSP), ciliated airway epithelial cells (β-tubulin IV), and endothelial cells (PECAM). No significant differences were observed among the lung with indicated different TACE genotypes. Cell nuclei were counterstained by DAPI (blue in A and B).