Skip to main content
. 2013 Oct 4;305(12):H1698–H1708. doi: 10.1152/ajpheart.00377.2013

Fig. 1.

Fig. 1.

Aging impairs adaptation of cerebrovascular myogenic autoregulation and smooth muscle cell (SMC) calcium signaling to hypertension. A: myogenic tone of middle cerebral arteries (MCAs) of young control, young hypertensive (young + ANG II), aged control, and aged hypertensive (aged + ANG II) mice. Data are means ± SE; n = 8 in each group. *P < 0.05 vs. young; #P < 0.05 vs. young + ANG II. Myogenic tone is expressed as percentage of the maximally dilated passive diameter of each vessel at the same intraluminal pressure. B: representative tracing of fura-2 340/380 fluorescence ratio in an isolated MCA showing increases in SMC intracellular Ca2+ concentration ([Ca2+]i) in response to depolarizing concentrations of KCl [60 mM; washout (WO)] and increased intraluminal pressure (160 mmHg). C: summary data showing increases in SMC [Ca2+]i in response to increases in intraluminal pressure to 80 and 160 mmHg. Data are expressed as percentage of KCl (60 mM)-induced calcium signals. Data are means ± SE; n = 8 in each group (*P < 0.05 vs. young; #P < 0.05 vs. young + ANG II). D: relationship between pressure (160 mmHg)-induced changes in SMC [Ca2+]i and myogenic tone of MCAs. Data are means ± SE; n = 8 in each group.