Fig. 2.
Role of 20-hydroxyeicosatetraenoic acid (HETE) in functional adaptation of MCAs to hypertension. A: increases in SMC [Ca2+]i in MCAs in response to increases in intraluminal pressure (from 20 mmHg to 160 mmHg) in the absence and presence of the specific cytochrome P-450 ω-hydroxylase inhibitor HET0016. Data are expressed as percentage of KCl (60 mM)-induced calcium signals. Data are means ± SE; n = 8 in each group (*P < 0.05 vs. young; #P < 0.05 vs. young + ANG II). B: relationship between pressure (160 mmHg)-induced changes in SMC [Ca2+]i and myogenic tone of MCAs of young and aged hypertensive mice in the absence and presence of HET0016. Data are means ± SE; n = 8 in each group.