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A: relationship between 20-HETE-induced changes in SMC [Ca2+]i and tone of control MCAs. Data are expressed as percentage of KCl (60 mM)-induced responses. Data are means ± SE; n = 8 in each group. B and C: 20-HETE-induced constrictions (B) and changes in SMC [Ca2+]i in MCAs isolated from young and aged mice. Data are means ± SE; n = 8 in each group. NS, nonsignificant.
