Fig. 11.

Cyclic changes in the eating-stimulatory effect of ghrelin in rats. The estrous cycle was monitored in intact rats (D1, diestrus 1; D2, diestrus 2; P, proestrus; E, estrus), and third cerebroventricular injections of 0.1 nmol of ghrelin or saline were tested on each cycle day. Ghrelin stimulated eating only on D1 and D2. *Significantly different from saline, same cycle day. Reprinted with permission from the American Diabetes Association from Diabetes, Deborah J. Clegg, Lynda M. Brown, Jeffrey M. Zigman, Christopher J. Kemp, April D. Strader, Stephen C. Benoit, Stephen C. Woods, Michela Mangiaracina, and Nori Geary, 56: April 2007; from Clegg et al. (130).