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Agouti-related peptide/neuropeptide Y (AgRP/NPY) neurons are necessary for the periovulatory decrease in eating in mice. Mice in which AgRP and NPY neurons were transgenically deleted (solid squares) did not show an estrous decrease in daily food intake under conditions in which wild-type control mice did (open symbols). M, diestrus 1; D, diestrus 2; P, proestrus; E estrus. From Olofsson et al. (527).
