Fig. 8.

Estradiol treatment reduced daily food intake (A) and body weight gain (B) in ovariectomized wild-type (WT) mice, but not in Erα^−/− mice. Constant-release estradiol pellets that produced plasma estradiol levels near the proestrous maximum or control vehicle pellets were subcutaneously implanted during ovariectomy. Data are from days 8–25 postoperatively because mice regained their presurgical weights by day 8. *Significantly less than control WT mice. Republished with permission from Geary at al. (257).