Table 5.
Pathways identified by GeneGo as significantly (corrected P value <0.05) altered in grazing cows UF compared with AF cows
| Pathway | P Value | % DEG | DEG |
|---|---|---|---|
| Oxidative phosphorylation | <0.0001 | 17.1 | NDUFA1, NDUFB3, NDUFS2, NDUFS3, NDUFS4, ATP5J, COX2, COX5A, COX7C, NDUFA4, NDUFA8, NDUFB6, NDUFC1, NDUFV3UQCR10, UQCRC2, UQCRH, UQCRQ |
| Immune response: histamine H1 receptor signaling | <0.001 | 20.8 | GNA11, NFATC1, JUN, PLCB3, PPP3CA, F3, GNB2/GNG12G, ICAM1, MAPK13, RELA |
| Transcription: transcription regulation of aminoacid metabolism | <0.001 | 28.0 | FECH, GCLM, HMBS, JUND/FOSL2, KEAP1, ODC1, PRKCE/PRKD2 |
| Cytoskeleton remodeling: TGF, WNT and cytoskeletal remodeling | <0.001 | 14.4 | ACTA2/ACTG1/ACTG2, ACTG1, CAV1, DVL2, FRAT1, JUN, KDR, MDM2, MKNK1, MYL12B, MYL4, COL4A5, MAPK13, NLK, RPS6KA5, TCF7 |
| Cytoskeleton remodeling: Cytoskeleton remodeling | <0.001 | 14.7 | ACTG1, CAV1, JUN, KDR, MKNK1, MYL12B, MYL4, COL4A5, EIF4A1, EIF4G1, EIF4G3, MAPK13, PTEN, RPS6KA5, TCF7 |
| Cell cycle: role of SCF complex in cell cycle regulation | <0.001 | 24.1 | CUL1, NEDD8, PLK1, CDT1, RBX1, SKP2 |
| Signal transduction: cAMP signaling | <0.001 | 21.1 | ADCY5, PHKG2, PPP3CA/B, PRKAR2A, PRKD2, RAP2A, ADCY6, GNB2/GNG12, |
| Protein folding and maturation: bradykinin/kallidin maturation | <0.01 | 21.9 | CPN2, THOP1, KNG1 |
| Development: beta-adrenergic receptors signaling via cAMP | <0.01 | 17.3 | ATP2A2, CAMK2D, PPARGC1A, PPP2CB, PPP3CB, PRKAR2A, ADCY6, MAPK13, PPKAR1B, |
| Development: notch signaling pathway | <0.01 | 18.6 | CUL1, HES1, JAG1, KAT2B, TLE3, GCN5, NFKBIA, NOTCH1, RBBP7, SAP30, SNW1 |
Boldfaced genes are upregulated, lightfaced genes are downregulated by energy restriction.
DEG, differentially expressed genes.