Table 6.
Metabolic networks identified by GeneGo as significantly (corrected P value <0.05) altered in grazing cows UF compared with AF cows
| Metabolic Network | P Value | % DEG | DEG |
|---|---|---|---|
| (L)-valine pathways and transport | <0.001 | 10.9 | ACSL1, JUN/JUND/FOSL2, PLCB3, SLC43A1, VARS, ACSL5, ICAM1, LHPP, LTA4H, PPA1 |
| GalNAcbeta1-3Gal pathway | <0.01 | 10.6 | CXCR4, EDNRA, EDNRB, F2RL2, GNAT1, PROC, AARS, GNA14, GNB2/GNG12, KHK, LARS2, LTA4H |
| Carbohydrate metabolism: TCA and tricarboxylic acids transport | <0.01 | 11.7 | DLD, IDH1, PC SLC25A21, SLC33A1, MDH1, SDHA, SDHC, SDHD, SLC13A2, SLC13A5, SUCLG2 |
| O-hexadecanoyl-(L)-carnitine pathway | <0.01 | 10.8 | ADCY5, CPT1A, CPT1B, GNAT1, PLCB3, ADCY6, GNB2/GNG12 |
| Lipid metabolism: fatty acid beta-oxidation | <0.01 | 8.9 | ACADVL, ACSL1, CPT1A, CPT1B, EHHADH, HSD17B4, HSD17B10, ACSL5, HMGCL |
| Phosphatidylinositol-4,5-diphosphate pathway | <0.01 | 9.4 | ACTN3, INPP5B, PLCB3, SPTBN2, ICAM1, INPP5F, OSBPL5, OSBPL9, OSBPL10, PLCD4, PTEN |
| Carbohydrate metabolism: Glycolysis, gluconeogenesis and glucose transport | <0.01 | 8.0 | ENO3, FBP1, FBP2, LDHB, SLC2A8, ALDOB, GPI, KHK, PGAM1, PGAM4, |
| Decanoylcarnitine pathway | <0.01 | 9.3 | CPT1A, CPT1B, CROT, FOXA2, SLC22A5, TLE3, GLI1, RORA, |
| Lauroylcarnitine pathway | <0.05 | 8.7 | CPT1A, CPT1B, CROT, FOXA2, SLC22A5, TLE3, GLI1, RORA, |
| 1-Akyl-glycerol_3-phosphoethanolamine pathway | <0.05 | 14.3 | GNA11, JUN, ICAM1, PAFAH1B2 |
| Sphingomyelin pathway | <0.05 | 7.8 | MED1, PLCB3, SORT1, SPHK1, CERS5, FABP1, RORA, SIRPA |
Boldfaced genes are upregulated, lightfaced genes are downregulated by energy restriction.