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. 2013 Sep 18;110(11):2627–2636. doi: 10.1152/jn.00052.2013

Fig. 1.

Fig. 1.

Altered cortical phenotype in CxNR1KO mice and immediate early gene, c-fos, expression in the barrel cortex following whisker stimulation. A and B: morphological appearance of the barrel cortex in control (A) and CxNR1KO (B) mice. Vesicular glutamate transporter 2 (VGLUT2) immunostaining reveals thalamocortical afferent (TCA) terminal patterns (blue) and NeuN immunostaining cellular, barrel patterns (yellow). The 1st micrograph in each horizontal series is an overlay of the 2 staining patterns. Note that in the CxNR1KO cortex TCA, patterns are smaller and less defined and there is no cellular patterning. C and C’: examples of barrel cortex from 2 different control cases immunostained for VGLUT-2 for TCA patterning (blue) and c-fos for immediate early gene expression (orange) following row C whisker stimulation. Whisker representations for rows A–E are indicated (also in Fig. 2). Note that c-fos immunoreactivity is mostly confined to C row barrels. D and D’: c-fos immunostaining in CxNR1KO cortex (orange) from 2 different cases shows diffuse staining without any patterning after row C whisker stimulation. Scale bar = 200 μm.