Fig. 4.

Temporal summation of repetitive thalamic inputs is impaired in CxNR1KO mice. A: all excitatory postsynaptic potentials (EPSPs) induced by stimulation of VPM with 7 pulses at 20 Hz are overlapped to build up a membrane depolarization in control mice. C: plot averaged peak amplitude shows temporal summation curve of EPSPs (solid line, n = 16). B: in CxNR1KO mice, EPSPs cannot build up a membrane depolarization. The averaged peaks of subsequent EPSPs are gradually lower than the 1st (Fig. 2C, dash line; n = 20). D–F: in both control and CxNR1KO mice, layer IV excitatory cells show paired-pulse depression (PPD), and there is no significant difference in the paired-pulse ratio.