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. 2014 Jan 6;204(1):29–43. doi: 10.1083/jcb.201305017

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© 2014 Mejlvang et al.

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Figure 7. — Model illustrating how new histone supply controls mammalian DNA replication and genome integrity. Cells accommodate transient shortage of new histones by slowing down replication speed and maintaining PCNA on newly synthesized DNA, allowing nucleosome assembly once canonical histones become available. In contrast, persistent lack of new histones leads to DNA damage and potential loss of chromosomal stability.