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. 2014 Jan 6;204(1):129–146. doi: 10.1083/jcb.201305084

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© 2014 Zambrano et al.

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Figure 2. — THRB mediates TH-induced senescence in MEFs. (A) THRB and THRA levels in immortalized MEFs from Thra/Thrb KO mice transduced with an empty vector or the receptors. (B) PDLs in cells incubated with and without T3 at three consecutive passages (P < 0.0001, n = 3). (C) Percentages of SA-βgal⁺ cells at passage 3 (P < 0.0001, n = 3). (D) Percentages of cells with γ-H2AFX, TP53BP1 foci, and both markers (P < 0.0001, n = 3). (E) SA-βgal⁺ MEFs after 3 d of treatment with T3 or GC-1 in a serum replacement medium (P < 0.0001, n = 3). Bars, 20 µm. (F) SA-βgal in MEFs subjected to a 2-h shock with 600 µM H₂O₂ and incubated with or without T3 during 3 or 9 d postshock (d.p.s). P1, passage 1; P3, passage 3. (P < 0.0001, n = 3). Results are presented as means ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001.