Fig. 4.

NMDA receptors have a significant role in RGC light responses. A: the application of 100 μM d,l-2-amino-phosphonoheptanoate (AP7) reduced the light responses recorded in voltage-clamp recordings from RGCs in wild-type and mutant retinas. B: current-clamp recordings of light responses from RGCs of wild-type and mutant retinas in normal Ringer and with the addition of AP7. C: light responses, normalized to control, recorded following the application of AP7 shown as total charge, peak amplitude, and spikes. Significance: compared with control (*) and between wild-type and mutant (**).