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Table I: Advantages of DNA vaccines.

Advantages of DNA vaccines References
Inexpensive 27
Long-term persistence of immunogenicity 19
Subunit vaccination with no risk for infection 28
Antigen presentation by both MHC class I and class II molecules 28
Ability to polarize T-cell help toward type 1 or type 2 28
Ease of development and production 27,28
Immune response focused only on antigen of interest 23
Stability of vaccine for storage and shipping 25
In vivo expression ensures that the protein resembles the normal eukaryotic structure more closely, with accompanying post-translational modifications 19
DNA vaccines are safer, more stable, and easy to handle 29
DNA vaccines induce protective humoral and cellular immune responses 30
DNA vaccines are heat stable 27
A mixture of plasmids could be used to form a broad spectrum vaccine 25