Figure 6.

Injection of GFP⁺ NPCs into lesions within neonatal embryonic neocortex results in viable neuronal transplants. (A,A’) Representative examples of an injury site 7 days after injection of GFP⁺ NPCs into the lesion. Subcortically projecting GFP⁺ fibers arising from the transplant are indicated with red arrows. The inset in (A) depicts the approximate region of injury within each slice. (B) Presumed axons arising from the transplant tended to form dense projections when projecting subcortically. (C) Example of spontaneous synaptic activity in a transplanted GFP⁺ neuron. (D) Firing patterns typical of fast spiking (FS, left) and regular-spiking (RS, right) neurons recorded from transplanted cells. Bottom trace depicts the depolarizing current command. Scale bars in (A,A’) are 250 and 100 μm in(B).