Table 3.
Associations between telomere length a and worst biopsy diagnosis
| |
|
Esophagitis |
Low-grade dysplasia
b
|
High-grade dysplasia
c
|
|||
|---|---|---|---|---|---|---|---|
| Controls | Cases | OR (95% CI) | Cases | OR (95% CI) | Cases | OR (95% CI) | |
| Unadjusted |
|
|
|
|
|
|
|
| Continuousd |
92 |
50 |
0.90 (0.68-1.18) |
37 |
1.14 (0.86-1.51) |
52 |
1.14 (0.89-1.46) |
| Quartiles |
|
|
|
|
|
|
|
| <0.784 |
23 |
10 |
ref |
4 |
ref |
10 |
ref |
| 0.784 - <0.925 |
23 |
24 |
2.40 (0.94-6.13) |
14 |
3.50 (1.00-12.25) |
14 |
1.40 (0.52-3.79) |
| 0.925 - <1.047 |
23 |
5 |
0.50 (0.15-1.69) |
9 |
2.25 (0.61-8.36) |
13 |
1.30 (0.48-3.56) |
| ≥1.047 |
23 |
11 |
1.10 (0.39-3.09) |
10 |
2.50 (0.68-9.13) |
15 |
1.50 (0.56-4.03) |
| p-trend |
|
|
0.031 |
|
0.224 |
|
0.870 |
| Adjustede |
|
|
|
|
|
|
|
| Continuousd |
92 |
50 |
0.91 (0.68-1.21) |
37 |
1.16 (0.87-1.54) |
52 |
1.20 (0.92-1.56) |
| Quartiles |
|
|
|
|
|
|
|
| <0.784 |
23 |
10 |
ref |
4 |
ref |
10 |
ref |
| 0.784 - <0.925 |
23 |
24 |
2.46 (0.89-6.80) |
14 |
4.80 (1.26-18.35) |
14 |
1.51 (0.54-4.24) |
| 0.925 - <1.047 |
23 |
5 |
0.59 (0.16-2.13) |
9 |
3.07 (0.78-12.06) |
13 |
1.50 (0.52-4.27) |
| ≥1.047 |
23 |
11 |
1.08 (0.36-3.28) |
10 |
3.05 (0.80-11.66) |
15 |
1.83 (0.65-5.12) |
| p-trend | 0.060 | 0.107 | 0.713 | ||||
aCalculated as telomeric DNA (T) divided by amount of single-copy control gene DNA (S) to produce the relative measurement of telomere length (T/S ratio).
bLow-grade dysplasia category includes mild dysplasia cases.
cHigh-grade dysplasia category includes moderate and severe dysplasia cases.
dContinuous telomere length scaled by half the interquartile range based on the distribution among the normal controls.
eModels adjusted for age, sex, BMI, tobacco smoking, alcohol drinking, and hypertension.
Abbreviations: OR, odds ratio; CI, confidence interval; BMI, body mass index.