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. 2013 Sep 25;14:654. doi: 10.1186/1471-2164-14-654

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Copyright © 2013 Fong et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Human A2M alpha-2-macroglobulin (GeneID 2) and its orthologs from 9 species. Reference species are marked with *. Each of these genes encodes a single RefSeq protein. This schematic shows the sequence alignment. Protein-coding regions were mapped to sequence with vertical green lines showing splice boundaries (7 proteins have 36 coding exons; others are truncated or extended). In reality, splice boundaries will not all align perfectly. Annotations predicted from sequence include signal peptide and five distinct CDD superfamilies.