Table 1.
JALSG-ALL202 chemotherapy protocol.
| Phase | Drug | Dosage | Days |
|---|---|---|---|
| Induction | Cyclophosphamide | 1200 mg/m2 | 1 |
| Daunorubicine | 60 mg/m2 | 1-3 | |
| Vincristine | 1.3 mg/m2* | 1, 8, 15, 22 | |
| L-Asparginase | 3000 U/m2 | 9, 11, 13, 16, 18, 20 | |
| Prednisolone | 60 mg/m2 | 1-21** | |
| Consolidation Phase I & IV | Cytarabine | 2000 mg/m2 | 1-3 (twice a day) |
| Etoposide | 100 mg/m2 | 1-3 | |
| Dexamethasone | 40 mg/bodies | 1-3 | |
| Consolidation Phase II & V | Methotrexate | 1500 mg/m2 | 1, 15 |
| Vincristine | 1.3 mg/m2* | 1, 15 | |
| Mercaptopurine (6-MP) | 25 mg/m2 | 1-21 | |
| Consolidation Phase III | Vincristine | 1.3 mg/m2* | 1, 8, 15 |
| Doxorubicin | 30 mg/m2 | 1, 8, 15 | |
| Dexamethasone | 10 mg/m2 | 1-8, 15-22 | |
| Cyclophosphamide | 1000 mg/m2 | 29 | |
| Mercaptopurine (6-MP) | 60 mg/m2 | 29-42 | |
| Cytarabine | 75 mg/m2 | 29-33, 36-40 | |
| Maintenance (repeat until 2 years from onset) | Vincristine | 1.3 mg/m2* | 1 |
| Prednisolone | 60 mg/m2 | 1-5 | |
| Methotrexate | 20 mg/m2 | 1, 8, 15, 22 | |
| Mercaptopurine (6-MP) | 60 mg/m2 | 1-28 |
*Max 2 mg
**tapered in 1 week, days 22-28.