Table 2.

Spectrum of dermatological reactions to EGFR inhibitors³⁹

Adverse Event	Description	Frequency	Time Course
Rash (follicular-pustular)	Monomorphous erythematous maculopapular, follicular or pustular lesions, which may be associated with mild pruritis	60–80%	Onset: treatment week 1.
			Maximum: treatment week 3–5.
			Resolution: within 4 weeks of treatment cessation, may wax and wane or resolve spontaneously
Paronychia and fissuring	Painful periungual granualtion-type or friable pyogenic granuloma-like changes, associated with erythema, swelling and fissuring of lateral nailfolds and/or distal finger tufts.	6–12%	Onset: treatment month 2–4
Dry skin	Diffuse fine scaling	4–35%	Occurs after appearance of rash