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. Author manuscript; available in PMC: 2014 Jan 7.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2012 Nov 13;5(1):10.1002/wsbm.1194. doi: 10.1002/wsbm.1194

Figure 1. Receptor Mediated Induction of LAT Phosphorylation.

Figure 1

TCR and CD2 induction results in the receptor localization and/or activation of the Src family kinases Lck and Fyn. The kinases then phosphorylate ITAM motifs on the TCR. This leads to the recruitment and activation of ZAP-70 and this kinase subsequently phosphorylates LAT. Activation of CD5, CD9 and CD28 enhance TCR-mediated LAT phosphorylation via an unknown mechanism. CD28 induction alone is also capable of inducing LAT phosphorylation by an uncharacterized mechanism.