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. Author manuscript; available in PMC: 2014 Jan 7.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2012 Nov 13;5(1):10.1002/wsbm.1194. doi: 10.1002/wsbm.1194

Figure 2. Recruitment of Complexes Containing PLCγ1, Gads and SLP-76 to LAT.

Figure 2

LAT phosphorylation results in the binding of PLCγ1 to LAT Y132 and Gads to LAT Y171 or Y191. Gads also binds to SLP-76, which stabilizes the interaction of PLCγ1 with LAT. PLCγ1 cleaves PIP2 into IP3, which induces calcium influx, and DAG, which activates RasGRP and PKC isoforms. SLP-76 is phosphorylated by ZAP-70 and subsequently binds ITK, which phosphorylates and activates PLCγ1, and Vav and Nck, which are critical for actin polymerization. SLP-76 is also required for the induction of PI3 kinase, resulting in the induction of numerous downstream pathways.