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. Author manuscript; available in PMC: 2014 Jan 7.
Published in final edited form as: Wiley Interdiscip Rev Syst Biol Med. 2012 Nov 13;5(1):10.1002/wsbm.1194. doi: 10.1002/wsbm.1194

Figure 4. Grb2/SH3 Domain Ligand Complexes Facilitate LAT Clustering.

Figure 4

Phosphorylated LAT is capable of simultaneously binding three Grb2 proteins. At the same time, Grb2 is dimerized by its SH3 domain ligands Sos1 and c-Cbl. The ability to bind multiple Grb2 molecules and the dimerization of Grb2 leads to the formation of a lattice of LAT that drives LAT clustering.