Figure 3.
CD8+ T-cell responses in vaccinated animals following SIVmac239 infection. Peptide/Mamu-B*08 tetramer staining in A) PBMC, B) lymph nodes, and C) colon biopsies. Error bars represent standard error of the mean. D) Correlations between the frequency of tetramer+ cells and VL at week 2 post infection. E) Granzyme B production by SIV-specific CD8+ T-cells in Group 1 and Group 2 vaccinees at days 7 and 17 post-infection. F) Perforin production by SIV-specific CD8+ T-cells in Group 1 and Group 2 vaccinees at day 17 post-infection. Assay results are shown as sport forming cells (SFC) per 106 PBMC.