Table 1.
Baseline demographic and clinical features (n = 26)
| Feature | |
|---|---|
| Age (yr) | 48.2 ± 11.8 |
| Sex (n, % female) | 10 (39) |
| Ethnicity (n, % minority) | 8 (31) |
| Body mass index (kg/m2) | 29.1 ± 5.9 |
| Received psychiatric disability (n, % yes) | 12 (46) |
| Education (yr) | 15.2 ± 2.7 |
| IQa | 114.9 ± 10.2 |
| Number of adequate antidepressants trials (median, range)b | 6.0 ± 4.1 (5, 2–18) |
| Past lamotrigine exposure (n, % yes) | 11(42) |
| Age at first major depressive episode (yr) | 18.5 ± 12.2 |
| Duration of index episode (yr) | 24.3 ± 16.3 |
| Ultrachronicc (n, %) | 24 (92) |
| Previous episodes (n) | 1.9 ± 1.7 |
| Comorbid anxiety disorder (n, % yes) | 20 (77) |
| Family history of alcohol use disorder (n, % yes) | 10 (39) |
| Past alcohol use disorder (n, % yes) | 6 (23) |
| Past substance use disorder (n, % yes) | 5 (19) |
| Family history of major depression (n, % yes) | 13 (50) |
| Baseline IDS-C30 | 47.0 ± 7.7 |
| Baseline MADRS | 36.9 ± 5.4 |
| Baseline QIDS-SR16 | 18.6 ± 3.9 |
| Baseline Clinical Global Impression – Severity | 5.3 ± 0.8 |
| Expectancy rating patient outcome (1–5) | 2.9 ± 1.0 |
IDS-C30, Inventory of Depressive Symptoms-Clinician Rated; MADRS, Montgomery–Asberg Depression Rating Scale ; QIDS-SR16, Quick Inventory of Depressive Symptomatology-Self-Report.
Values are mean ± s.d. unless otherwise indicated.
a
Weschler Abbreviated Scale of Intelligence (WASI).
b
Antidepressant Treatment History Form, minimum score of 3 (threshold for classification as medication resistant).
c
index major depressive episode ≥42 months (Gilmer et al. 2008).