Table 1.
Unadjusted Hazard Ratios (HRs) for the Development of Fluoroquinolone (FQ)–Resistant Escherichia coli Colonization, by Baseline and Time-Varying Characteristics
| Variable | Value (n = 57) | HR (95% CI) | P |
|---|---|---|---|
| Age, y, mean ± SD | 76.6 ± 12.3 | 1.02 (.99–1.04) | .16 |
| Female sex | 15 (26.3) | 1.43 (.79–2.60) | .24 |
| Nonwhite race | 29 (50.9) | 1.14 (.67–1.95) | .63 |
| Site | |||
| LTCF 1 | 20 (35.1) | Reference | |
| LTCF 2 | 33 (57.9) | 0.86 (.49–1.50) | .59 |
| LTCF 3 | 4 (7.0) | 0.68 (.23–2.00) | .48 |
| Hospitalization in past year | 43 (75.4) | 1.22 (.66–2.24) | .52 |
| Comorbidity or medicationa | |||
| Severe cardiovascular disease | 10 (17.8) | 1.57 (.78–3.14) | .21 |
| Fecal incontinence | 27 (47.4) | 1.80 (1.06–3.04) | .03 |
| FQ receipt in past 30 d | 1 (1.8) | 2.32 (.31–17.3) | .41 |
| Time-varying characteristic after enrollment | |||
| Amoxicillin-clavulanateb | 9 (15.6) | 7.63 (1.75–33.3) | .007 |
| Any antibiotic | 25 (43.9) | 0.63 (.15–2.64) | .53 |
| Bed-bound status | 1 (1.8) | 2.02 (.49–8.43) | .33 |
| Wheelchair dependent | 24 (42.9) | 1.46 (.85–2.51) | .17 |
| Urinary catheter | 6 (10.5) | 3.03 (.89–10.3) | .08 |
Data are presented as no. (%) of patients who developed FQ-resistant E. coli colonization, unless otherwise indicated.
Abbreviations: CI, confidence interval; LTCF, long-term care facility.
a Only baseline characteristics with P < .30, except FQ use, are shown.
b All other antibiotics had a P value of > .30.