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Compound 7w (VU0452865) and compound 12a (VU0455691) selectively antagonize M1 when compared to M2-5 receptors. CRCs were obtained in the presence of an EC80 concentration of ACh for each receptor in calcium mobilization assays. Data were normalized to the maximum response of 30 μM ACh and are presented as a percentage of the EC80 ACh response.
