Table 1.
Demographics, viral and coreceptor characteristics
| Couple | Type 1 | Int. days 2 | Partner interval 3 | Recipient CCR5 4 | Recipient CXCR4 5 | Recipient tropism 6 | Transmitter CCR5 | Transmitter CXCR4 | Transmitter tropism |
|---|---|---|---|---|---|---|---|---|---|
| HF |
FTM |
17 |
3 |
7.24 |
<0.1 |
R5 |
8.27 |
<0.1 |
R5 |
| 888 |
MTF |
74 |
19 |
10.39 |
<0.1 |
R5 |
11.91 |
<0.1 |
R5 |
| 890 |
MTF |
138 |
12 |
3.79 |
<0.1 |
R5 |
2.27 |
<0.1 |
R5 |
| 394 |
MTF |
93 |
2 |
7.79 |
<0.1 |
R5 |
10.85 |
<0.1 |
R5 |
| 927 |
MTF |
324 |
46 |
12.55 |
<0.1 |
R5 |
13.37 |
<0.1 |
R5 |
| 2769 |
MTF |
149 |
46 |
5.69 |
<0.1 |
R5 |
5.34 |
0.65 |
R5/X4 |
| 2810 |
MTF |
161 |
23 |
5.49 |
<0.1 |
R5 |
6.12 |
<0.1 |
R5 |
| SR-5 |
MTF |
17 |
0 |
12.62 |
<0.1 |
R5 |
9.72 |
<0.1 |
R5 |
| SR-20 | MTF | 91 | 34 | 6.70 | <0.1 | R5 | 7.24 | <0.1 | R5 |
1FTM: female to male; MTF: male to female.
2Interval in days from the estimated date of acquisition to the day of sample collection for the newly infected partner. For seronegative individuals, interval was estimated as a maximum of 17 days.
3Interval in days between sampling of the two partners within a couple.
4P24 (ug/ml) from U87/CD4/CCR5 cells at day 4 post-infection.
5 P24 (ug/ml) from U87/CD4/CCR5 cells at day 4 post-infection.
6Tropism as determined on U87/CD4+/CCR5 and U87/CD4+/CXCR4 cells.