Table 1.
Effect of Metformin on Tumor Weight in Mouse Xenografts
| Cell Line |
Mice (n) |
Developed Tumor n (%) |
Time to Moribund (days) |
Mean Tumor weight (g) |
Mean Mouse Weight (g) |
Mean Serum ALTa (U/L) |
|---|---|---|---|---|---|---|
| Hec1A | 20 | 20 (100%) | 50 | Control: 0.40 Metformin: 0.22 *p=0.002 |
Control: 27.01 Metformin: 25.97 p=0.281 |
Control: 17.5 Metformin: 22.0 p=0.228 |
| Ishikawa | 20 | 20 (100%) | 64 | Control: 1.12 Metformin: 0.87 p=0.337 |
Control: 26.28 Metformin: 26.24 p=0.971 |
Control: 30.0 Metformin: 37.7 p=0.616 |
| MecPK | 20 | 17 (85%) | 29 | Control: 1.37 Metformin: 0.72 *p=0.024 |
Control: 26.41 Metformin: 24.95 p=0.420 |
Control: 13.7 Metformin: 17.0 p=0.059 |
a
Alanine aminotransferase (ALT), a marker of liver toxicity.