Table 4.
Colorectal cancer
|
Colon cancer
|
Rectal cancer
|
Heterog. p-valueb | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | ORa | 95% CI | p-value | N | ORa | 95% CI | p-value | N | ORa | 95% CI | p-value | ||
≤ 3/>3 | ≤ 3/>3 | ≤ 3/>3 | |||||||||||
Ile/Ile | 164/80 | 1ref | 107/42 | 1ref | 33/29 | 1ref | |||||||
Ile/Val | 195/55 | 0.58 | 0.39-0.86 | 0.007 | 126/32 | 0.65 | 0.38-1.09 | 0.106 | 50.16 | 0.36 | 0.17-0.77 | 0.008 | |
Val/Val | 59/14 | 0.49 | 0.26-0.92 | 0.028 | 29/9 | 0.79 | 0.34-1.81 | 0.578 | 19/3 | 0.18 | 0.05-0.67 | 0.011 | |
per Val allele | 0.65 | 0.49-0.87 | 0.004 | 0.79 | 0.54-1.16 | 0.232 | 0.40 | 0.22-0.70 | 0.001 | 0.043 |
Case-only analyses were done using unadjusted unconditional logistic regression models using the dichotomized exposure as the outcome variable, using individual SNPs as the independent variables to obtain ORs that would be equivalent to interaction OR (IOR).
colon vs rectum heterogeneity test;
pan-fried, oven-broiled, or grilled