TABLE II.
Cytoarchitectural Features of the MDA PCa 144-4 and MDA PCa 144-13 Xenografts and Their Tissue of Origin
| Feature | Adenocarcinoma | LCNEC | MDA 144-4 | SCC |
MDA 144-
13 |
|---|---|---|---|---|---|
| Architecture | Irregular fused glands/cribriform |
Diffuse pattern, nodules and solid sheets with occasional |
Diffuse
pattern, nodules and solid sheets with rosettes |
Diffuse pattern |
Diffuse
focally nested pattern |
| Cell size | Medium to large | Large | Large | Medium | Medium |
| Nuclear size | Small to medium | Large | Large | Medium | Medium |
|
Nuclear
shape |
Round | Oval or elongated |
Oval or
elongated |
Round | Round |
| Cytoplasm | Abundant, clear | Abundant, amphopihilc |
Abundant,
amphopihilc |
Scanty | Scanty |
| Chromatin | Vesicular | Vesicular | Vesicular | Salt-and- pepper stippled |
Salt-and-
pepper stippled |
| Nucleoli | Prominent; 1 centrally located |
Prominent; 1 or 2 centrally or peripherally |
Prominent;
centrally located |
Indistinct | Indistinct |
|
Mitotic
index |
1 or 2 per 10 HPF | 15 per 10 HPF |
>20 per 10 HPF |
15 per 10 HPF |
>20 per 10 HPF |
| Apoptosis | Absent | Present (abundant) |
Present
(abundant) |
Present (abundant) |
Present
(abundant) |
| Necrosis | Absent | Present | Present | Present | Present |
|
Percentage
of tumor mass |
20 | 10 | 70 |
Abbreviations: LCNEC, large-cell neuroendocrine carcinoma; SCC, small-cell carcinoma; HPF, high-power microscope field.