Table 3.
FeNO adjusted associations with natural-log-transformed microbial agent concentrations, reported home dampness and pet ownership
| |
|
|
Combined (random effects) |
|||
|---|---|---|---|---|---|---|
| |
LISA |
PIAMA |
INMA |
Total |
Not reported allergies |
Reported allergies |
| β (95% CI) | β (95% CI) | β (95% CI) | β (95% CI) | β (95% CI) | β (95% CI) | |
|
Microbial agents concentrations |
|
|
|
|
|
|
| Endotoxin (log(EU/mg)) |
0.01 (-0.11; 0.13) |
-0.08 (-0.17; 0.01) |
-0.06 (-0.11; 0.00) |
-0.05 (-0.10; -0.01) |
-0.06 (-0.11; -0.01) |
-0.06 (-0.14; 0.03) |
| EPS (log(U/mg)) |
-0.03 (-0.16; 0.11) |
0.02 (-0.07; 0.11) |
0.06 (-0.05; 0.17) |
0.02 (-0.04; 0.08) |
0.07 (0.00; 0.15) |
0.08 (-0.05; 0.20) |
| Glucan (log(μg/mg)) |
-0.07 (-0.28; 0.15) |
0.02 (-0.10; 0.13) |
- |
0.00 (-0.10; 0.10) |
0.00 (-0.21; 0.21) |
0.04 (-0.15; 0.24) |
| |
GM ratio (95%CI) |
GM ratio (95%CI) |
GM ratio (95%CI) |
GM ratio (95%CI) |
GM ratio (95%CI) |
GM ratio (95%CI) |
|
Dampness at home |
|
|
|
|
|
|
| Never |
1 |
1 |
1 |
1 |
1 |
1 |
| Ever during the first 2 years of life |
1.01 (0.80-1.26) |
0.89 (0.73-1.1) |
1.03 (0.85-1.24) |
0.97 (0.87-1.10) |
0.93 (0.81-1.06) |
1.14 (0.8-1.63) |
|
Cat ownership |
|
|
|
|
|
|
| Never |
1 |
1 |
1 |
1 |
1 |
1 |
| Ever during the first 2 years of life |
0.97 (0.71-1.33) |
0.89 (0.70-1.13) |
0.83 (0.65-1.06) |
0.89 (0.76-1.03) |
0.98 (0.78-1.22) |
0.72 (0.51-1.04) |
| Ever after the first 2 years of life |
0.87 (0.64-1.19) |
0.96 (0.65-1.43) |
1.22 (0.88-1.69) |
1.01 (0.82-1.24) |
1.11 (0.90-1.37) |
0.83 (0.52-1.32) |
|
Dog ownership |
|
|
|
|
|
|
| Never |
1 |
1 |
1 |
1 |
1 |
1 |
| Ever during the first 2 years of life |
1.04 (0.65-1.68) |
0.89 (0.66-1.20) |
0.75 (0.62-0.92) |
0.82 (0.70-0.96) |
0.88 (0.74-1.04) |
0.69 (0.51-0.94) |
| Ever after the first 2 years of life | 0.83 (0.57-1.21) | 1.18 (0.80-1.76) | 1.00 (0.75-1.33) | 0.99 (0.81-1.21) | 1.02 (0.82-1.27) | 1.28 (0.5-3.29) |
Adjusted for sex, age of FeNO measurement, asthma, reported allergies, parental smoking at the moment of the FeNO measurement, and parental education. Models including endotoxin, EPS and glucan measurements were additionally adjusted for season of dust sampling. Models stratified by reported allergies were not adjusted for reported allergies. All the heterogeneity tests were not significant (p-values ≥ 0.05).