Table 1.
Characterization of Tet-NPs with different drug feeding
| Tet feeding (copolymer based w/w) | Size (nm)a/PDI | Zeta potential (mV) | DLC (%) | EE (%) |
|---|---|---|---|---|
| 0 | 125.3±7.3/0.13 | −3.8±0.5 | N/A | N/A |
| 10% | 115.5±6.9/0.14 | −4.5±0.4 | 9.3±2.1 | 91.2±5.1 |
| 20% | 120.2±8.2/0.13 | −5.6±1.1 | 15.2±3.5 | 89.3±7.3 |
| 40% | 111.4±9.2/0.14 | −6.2±1.2 | 27.4±4.2 | 83.2±5.9 |
a
Note: Mean diameter was measured by dynamic light scattering.
Abbreviations: Tet-NPs, tetrandrine-loaded poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles; PDI, polydispersity index; DLC, drug loading content; EE, encapsulation efficiency; Tet, tetrandrine.