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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Hum Mutat. 2013 Jul 11;34(10):10.1002/humu.22367. doi: 10.1002/humu.22367

Figure 1.

Figure 1

Pedigree and clinical features of the family with bilateral microtia and hearing loss. A: Pedigree showing individuals affected with microtia and hearing loss. The labeled individuals (I.1, II.1, II.2, II.3, II.4, III.1, III.2, and III.3) were enrolled in the study. Individuals marked as +/− are heterozygous for the HOXA2 Q235* variant. Individuals marked as −/− do not carry the Q235* variant. B: Pictures of the right and/or left ears of several family members. C: Pure-tone audiometry for family members III.2 and III.1 measuring air and bone conduction of sound. Normal air and bone conduction at different frequencies (Hz) is above the solid horizontal line. Individual III.2 has mixed (diminished bone and air conduction) hearing loss that is moderate in the right ear and severe in the left ear. Individual III.1 has moderate mixed hearing loss in the right ear and mild conductive hearing loss in the left ear.